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Cases like this will make or break a career.

Bill Cosby went on trial today on charges he drugged and sexually assaulted a woman more than a decade ago, with prosecutors immediately introducing evidence the 79-year-old TV star once known as America’s Dad had done it before to someone else.

The prosecution’s opening witness was not the person Cosby is charged with abusing, but another woman, who broke down in tears as she testified that the comedian violated her in the mid-1990s at a hotel bungalow in Los Angeles.

Cosby is on trial on charges he assaulted Andrea Constand, a former employee of Temple University’s basketball program, at his suburban Philadelphia mansion in 2004. His good-guy reputation already in ruins, he could get 10 years in prison if convicted.

In her opening statement, prosecutor Kristen Feden noted that the “Cosby Show” star previously admitted under oath that he gave Constand pills and touched her genitals as she lay on his couch.

“She couldn’t say no,” Feden said. “She can’t move, she can’t talk. Completely paralyzed. Frozen. Lifeless.”

Cosby attorney Brian McMonagle countered by attacking what he said were inconsistencies in Constand’s story, disputed that Constand was incapacitated and made the case that she and Cosby had a romantic relationship.

He said Constand initially told police that she and Cosby did not speak after their 2004 encounter, when, in fact, phone records show the two talked 72 times, with 53 of those calls initiated by Constand.

Constand, 44, of the Toronto area, is expected to take the stand this week and tell her story in public for the first time.

The trial’s first witness was Kelly Johnson of Atlanta, who worked for one of Cosby’s agents at the William Morris Agency. She described an encounter she said took place in 1996 at the Hotel Bel-Air when she was in her mid-30s.

Prosecutors are trying to show Cosby’s treatment of Constand fit a pattern of predatory behavior.

They had wanted to call as many as 13 women who say Cosby sexually assaulted them, out of more than 60 accusers in all. But Judge Steven O’Neill, in a victory for Cosby, said the jury could hear only from Constand and Johnson.

Johnson testified that Cosby pressured her to take a large white pill that knocked her out, and when she woke up he put lotion on her hand and forced her to touch his genitals.

“My dress was pulled up from the bottom, and it was pulled down from the top, and my breasts were out,” she said, crying. “And I felt naked.”

Cosby’s lawyer argued that Johnson was seeking a payout from the TV star.