The reduced barometric pressure at higher altitudes leads to a decrease in oxygen pressure. This makes it necessary to pressurize cabins in planes. And for mountaineers tackling high altitudes to carry supplemental oxygen.
Effects of Hypoxia
Hypoxia manifests gradually, inducing a state of drowsiness and impaired cognitive function. Eventually, unconsciousness follows, often with a narrow window of opportunity for the pilot to put on an oxygen mask.
The ill-fated Virginia flight’s pilot had only a limited timeframe to react. The aircraft ascended to 34,000 feet and remained at that altitude for the entirety of the flight.
The intercepting NORAD jets did not see visible frosting on the interior windows which occurs in a catastrophic pressurization failure. But visibility could be an issue.
Experts note that autopilot systems, commonly used in flights, continue flying pre-programmed routes in the event of pilot incapacitation.
The sudden change in the course during the Virginia crash raises questions of possible pilot disorientation. Or attempts to reprogram the flight computer while experiencing hypoxia.