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In a bold move to reshape how technology serves the nation’s most overlooked patients, Town Hall Ventures announced Wednesday the launch of its $440 million Fund IV, aimed at fueling artificial intelligence and healthcare innovation for underserved communities across the U.S.

The firm’s latest fund marks another milestone in its ongoing mission to tackle healthcare inequities through venture-backed technology and data-driven solutions.

Investing Where Healthcare Falls Short

“With Fund IV, we will accelerate our mission by backing founders and technologists who are using AI as a core capability to lower costs, improve outcomes, and expand access to high-quality care for tens of millions of people underserved by the healthcare system,” said Meera Mani, general partner at Town Hall Ventures.

The firm said the fund’s capital will help healthcare startups break through the toughest barriers to care, bringing innovation directly to communities often left behind by traditional providers.

A Mission Built on Impact and Scale

Founded in 2018, Town Hall Ventures has become one of the most mission-driven investment firms in the healthcare sector, boasting $1.4 billion in assets under management and a portfolio that now touches one in five Americans.

To date, the firm has invested in 42 companies spanning early-stage to growth-phase ventures, many of which are using AI to reimagine patient care.

Powering the Next Generation of Health-Tech Innovators

Among its portfolio highlights are Thyme Care, an oncology treatment platform; Strive Health, which deploys machine learning to manage kidney disease; Arine, a precision medication management system; and Ambience Healthcare, an AI platform that helps doctors with medical documentation and coding.

Renowned investor John Doerr, a longtime limited partner in the firm, praised Town Hall’s model of merging purpose with profit. “The obsession that the Town Hall team has with turning mission into business alpha has made it easy for me to join them in all four of their funds,” he said. “It takes a special group of people to see that intersection and turn it into reality.”

Expanding the Team for the Next Phase

Town Hall Ventures also revealed key leadership additions alongside the fund announcement. Catherine Olexa-Meadors, who previously worked with healthcare startups Aledade and Remedy Partners, joins as head of partnerships and growth. Meanwhile, Will Stokes, co-founder of Strive Health, will head Hatch, the firm’s company-creation studio focused on building new ventures from within.

The firm did not immediately disclose which law firm advised it on the Fund IV transaction.

With this latest $440 million investment, Town Hall Ventures continues to prove that healthcare innovation—when fueled by AI and equity—can be both a social mission and a market force driving the future of medicine.