The Company that is Making Marijuana Great Again – Kalytera

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Medical Marijuana is currently legal in 28 states, as well as Washington D.C. 2016 was a great year for the medical marijuana industry, with Arkansas, Florida, North Dakota, Ohio, and Pennsylvania implementing legislation and ballot initiatives to legalize medical use.  Along with these initiatives, industry leaders have taken steps to solidify their spot in the market, demonstrate earning potential, and debunk associated stigmas.

Political action aside, widespread use and adoption of any medical treatment requires vetting, and vetting relies on research.  Increased research into cannabidiol (CBD) is expected to strengthen the industry.  The Drug Enforcement Administration, the primary agency for federal enforcement of marijuana laws, has recently increased the number of authorized manufacturers that supply their research.  According to the agency, “This change illustrates the DEA’s commitment to working with the FDA and NIDA to facilitate research concerning marijuana and its components.”

Medical marijuana has seen a lot of interesting research over the last decade. It has been observed to have efficacy in relieving pain, anxiety, symptoms of Multiple Sclerosis, Glaucoma, and a wide variety of other medical conditions. Many of these symptoms are treated specifically using cannabidiol (CBD), a substance found in marijuana. CBD does not have the psychoactive qualities that many associate with recreational marijuana use.

“CBD has shown for some time now (decades) that it can have a medicinal effect.” Says CNN’s Dr. Sanjay Gupta. Gupta, a former critic of medical marijuana, has written articles and produced documentaries extolling the benefits of the controversial drug. According to Gupta, medical marijuana research “is about emerging science that not only shows and proves what marijuana can do for the body but provides better insights into the mechanisms of marijuana in the brain, helping us better understand a plant whose benefits have been documented for thousands of years.”

According to Dr. Raphael Mechoulam, Ph.D., “Cannabis has been used as a medicinal agent for thousands of years. We have evidence that the Assyrians used it in what seem to be neurological diseases, the Greeks and the Romans used it for inflammation.”

Mechoulam is the Co-Chair of the Scientific Advisory Board for Kalytera, a company that is working to develop proprietary drugs that use CBD. “Kalytera was established in order to evaluate and develop cannabinoid drugs…compounds based on the plant material…we’re studying the cannabinoid system and then preparing new compounds based on the cannabinoid system both in the plant and in the body to get better compounds, better drugs.”

Unfortunately, according to Kalytera, a company that is developing proprietary drugs that use CBD, “there are limitations associated with natural CBD, including its poor oral bioavailability and short half-life.”

Bioavailability is the portion of a drug or substance that can be absorbed and affect the body. Different methods of ingestion will affect the bioavailability. For example, when inhaled CBD has a bioavailability of 31%. In contrast, when it is taken orally, its bioavailability is only 6%.

Kalytera is working to create a new class of CBD drugs with increased bioavailability to deliver more effective doses to patients. They are doing this through research on two fronts.

 

The first front focuses on further research into the use of CBD. Combining what is already an impressive body of research on the substance with a more in-depth clinical analysis, Kalytera hopes “to expedite regulatory approval and commercialization.” Their CBD research includes several programs that study the efficacy of CBD in bone health and healing for patients with Osteoporosis, bone fractures, Osteogenesis imperfecta, and Prader-Willi Syndrome (PWS).

The second front involves developing and creating synthetic cannabinoids with better bioavailability to deliver more efficient doses.

Kalytera’s research programs study the use of CBD in conjunction with these synthetic cannabinoids in treating patients.

In the 1960’s, Dr. Raphael Mechoulam, an Israeli researcher, was one of the first to successfully identify THC and CBD, the main components of marijuana. His research led him to petition the Israeli Ministry of Health to approve medical marijuana in 1992 and establish a program for researchers and patients, a move which has positioned Israel at the forefront of medical marijuana research.

Kalytera, in efforts to further this research, has partnered with the Hebrew University of Jerusalem and exclusively licensed synthetic cannabinoids KAL 436/9 and 671.

Kalytera researchers have studied the ability of KAL436/9 to improve bone fracture healing and strengthen bones in patients suffering Osteogenesis imperfecta (brittle bone disease).

Researchers are exploring KAL671 for preventing bone loss in mice with PWS.  Thus far, it’s demonstrated the ability to restore bone growth and inhibit bone resorption.  It is also non-toxic in preclinical animal models.

On the 13th of January 2016, Kalytera announced that they have entered a binding letter of intent to acquire securities of Talent Biotechs Ltd., a private Israel-based developer of CBD therapeutics. Under this agreement, they have made a non-refundable payment of $1,000,000. This acquisition will allow Kalytera to further tap into the wealth of Israeli research on medical marijuana.

Talent is performing pioneering studies on the treatment of graft versus host disease (GvHD) – a potential complication in bone marrow transplant patients – and they have gained four orphan drug designations in the US and Europe. In May of 2015, Chief Medical Officer of Talent, Moshe Yeshurun, M.D., published a study demonstrating CBD’s efficacy in dealing with complications resulting from bone marrow transplants.

According to David Stefansky, Co-Founder of Kalytera and Chairman of the Board of Directors, “We are thrilled to announce the signing of this LOI, which brings us closer to acquiring a late-stage program in GvHD with strong proof-of-concept.  There are currently few options to prevent or treat GvHD. We feel incredibly fortunate to be working towards the advancement of this important program.”

Andrew Salzman, M.D., Kalytera Chief Executive Officer added, “Multiple studies have demonstrated that CBD possesses remarkable therapeutic potential across a broad range of diseases and disorders.  The proposed acquisition of Talent and its late-stage GvHD program significantly advances Kalytera’s mission of becoming a global leader in CBD pharmaceuticals. We are encouraged by Talent’s GvHD data, and we are hopeful that Kalytera will be able to rapidly advance the program into placebo-controlled, double-blind, randomized studies.”

Beyond their ground-breaking research, Kalytera has all the pieces in place to become a leader in the medical marijuana industry. They have assembled a leadership team composed of some of the greatest minds in medical research and development, including: David Stefansky, Co-Founder and Chairman, Andrew L. Salzman, MD., Chief Executive Officer and Chief Medical Officer, Raphael Mechoulam, Ph.D., Robert Farrell, President, COO and CFO, and Seth Yakatan, Co-founder and Director.

Kalytera announced on January 11th, 2017, that its common shares commenced trading on the TSX Venture Exchange. The shares are trading under “KALY.”

 

Comments From Facebook

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Marie Sloan: Marijuana was never great!
Posted ON : 01/18/2017
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Tim Dolliver: Always great, you mean?  
Posted ON : 01/18/2017
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Zhou Sei: dont knock it till youve tried it, marie  
Posted ON : 01/18/2017
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Grace N Bright Glassinger: Correct Maries Sloan. That's another dumb headline. Using it for medical reasons is good. Self medicating with it is not really smart  
Posted ON : 01/18/2017
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Steve Doll: Every day 😎  
Posted ON : 01/18/2017
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Alan Kenyon: I'm so glad that people are waking up to the fact that marijuana actually has medical benefits even to those that self medicate. This is a wonderful plant that helps anyone from simple anxiety issues, cancer, seizures, PTSD, wth no serious side effects like the pharmaceutical companies pills that kills more people than alcohol, guns violence.  
Posted ON : 01/18/2017
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John Cudworth: No serious side effects as long as you have not cardiac issues, are not at risk for stroke, have a completely matured brain, don't smoke or because the incidence of pneumonia is higher. Of course there is also the fact that you cannabanoid system is NOT designed to be overloaded. But yes, it does have some medical benifits. But it does not completely replace other medicarions. Which, by the way are often naturally sourced. The list of plant based medicines is quite long.  
Posted ON : 01/18/2017
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Wendy Block: Cannot be improved on!
Posted ON : 01/18/2017
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Marie Sloan: Never!!
Posted ON : 01/18/2017
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Steve Doll: Watering the garden with grandkids priceless 😎  
Posted ON : 01/18/2017
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Cody Robert: Just legalize it and STOP PUTTING CHEMICALS IM SOMETHING THAT DONT NEED IT FUCKING LORD
Posted ON : 01/18/2017
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Zhou Sei: dude... at least read the article before you make comments about it  
Posted ON : 01/18/2017
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Cody Robert: Zhou Sei um no pharmaceutical companies gonna ruin cannabis. USA trying so hard to make pills and patient it. You are a jack ass . I rather have the real deal then some pharmaceutical company trying to ruin cannabis. That's nothing new USA always disappoint everyone and ruin everything. All pharmaceutical companies want is to kill people and take your money  
Posted ON : 01/18/2017
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Mike Kramarenko: I was about to say the same thing. I man if they get their hands on it they would probably charge $10,000. For an oz.  
Posted ON : 01/18/2017
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Marie Sloan: Never have and never will!
Posted ON : 01/18/2017
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Rachel Hilliard: It is bad for your body it's all about money
Posted ON : 01/18/2017
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Jon Betts: I agree Cody Robert. All that pharmaceutical drugs do is keep you alive longer while you still suffer greatly. I smoked pot for 35 years and never had any adverse reactions to it at all and in fact it knocked the shit out of my migraines and took care of my back pain. Unfortunately I worked for 30 years in the foundry and smoked a pack of cigarettes a day for 40 years. It messed my lungs up pretty bad and although I can't smoke it no more I've tried some of the really good strains of oil and it's amazing for all kinds of pain plus the euphoria is better than anything I've ever smoked. It takes 2-3 hours to feel the full effect but I'm a patient man. It's been a few years since I've had anything because in Illinois it's still illegal without a medical card. If pharmas get ahold of it they'll surely fuck it up and jack prices way too high.
Posted ON : 01/18/2017
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Ken Tidwell: Marijuana is and has always been great - It's only bad programming and misconceptions that are changing - kinda like putting the cart in front of the horse aren't we ?
Posted ON : 01/18/2017
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Ron Ewald Drumbarger: Great again? Is this where trumpy got his slogan? With a doozie!!! LOL
Posted ON : 01/18/2017
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Brad Kicak: They're decades behind Cheech n Chong!
Posted ON : 01/18/2017
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Danny Newberry: Marie how is marijuana bad. Please leave some facts and not the made up ones people like to use.
Posted ON : 01/18/2017
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Ronald Kosanovich: Could give you a ton of them. Check state statistics in vehicle homicides related to recreational weed? Only facts, no bullshit  
Posted ON : 01/18/2017
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Danny Newberry: And look how many involve alcohol. Is that your only fact you have. If it is your argument is very shaky at best.  
Posted ON : 01/18/2017
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Ryne Siebel: Actually the contrary https://www.google.com/amp/www.forbes.com/sites/daviddisalvo/2016/12/31/states-with-medical-marijuana-laws-have-fewer-traffic-fatalities-but-why-isnt-clear/  
Posted ON : 01/18/2017
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Ryne Siebel: https://www.google.com/amp/s/patch.com/us/across-america/amp/26842487/medical-marijuana-laws-connected-to-fewer-traffic-deaths  
Posted ON : 01/18/2017
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Mike Kramarenko: I've been smoking it since I was 11. I'm 52 now and it's really inhanced my life in so many ways. Back in 1978 I was diagnosed with cancer, and the Drs. Told my parents I needed chemotherapy. That didn't go over well. Within 8 months I was cured without chemotherapy, and without big brothers pharmisudical B's. Im still cancer free and owe my life to the plant and my dealer. Any evedance that points to health problems and accidents is purely misleading and the product of assholes that want the big pharmisudical companies to have Controll and charge an astronomical amount. Don't play victim to the lies of a fucked up government.  
Posted ON : 01/18/2017
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Alan Kenyon: Marijuana is a wonderful, safe pant with so many cures from a simple anxiety issues, cancers, PTSD, without the killer side effects like the pharmaceutical companies pills that kills more people than gun violence, or alcohol.  
Posted ON : 01/18/2017
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Roy Luckett: I stopped doing drugs, and picked up the plant. No more oxys and taking my life back. I toke then run 2.22 miles 6 days a week. And jumprope after daily. I had a industrial accident 16 yrs ago and PHARMA DRUG DEALERS just wanted a repeat customer and raise the debt ceilings on ridicolous medical prescription prices. Over 6 outpatient surgeries and 4 major, titanium and carbon fiber neck and spine... Toss the pills and take your life back. No one else will surely help you.. the American Cancer $ociety and FDA buried the cure.. fact check out this documented proof from the 90s forbidden cure. "The Burzynsky Movie" i would add link, but it gets disabled fast... here i come MMA gonna be Like Nick Diaz a champ who Tokes.  
Posted ON : 01/18/2017
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Peggy Slack Crowley: Getting it
Posted ON : 01/18/2017
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Shari McDonald: That was totally uncalled for Sergio Marquez
Posted ON : 01/19/2017
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Alan Kenyon: He's just a young dumb kid with no knowledge of why the legalization of marijuana is happening. It's not because these young dumb kids fought for the legalization. It's because us old fucks continued to fight for the legalization before this young dumbass was even born and us old fucks were the ones that started cultivating marijuana to be better back in the 60's. But I'm sure this smart young dumbass knew that..  
Posted ON : 01/19/2017
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Darian L. Smith: It was uncalled for but it was also hilarious.  
Posted ON : 01/19/2017
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Darrell Ernst: It has been great since man learned to walk. It is the miss informed public that needs to be made great again.
Posted ON : 01/19/2017
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Ronald Kosanovich: Joke. Illegal drugs will skyrocket now that they'll have a legal pass to carry.
Posted ON : 01/19/2017
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Jani Patereau: And, crimes committed while under the influence will skyrocket.  
Posted ON : 01/19/2017
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Alan Kenyon: Oh my god.. the two uninformed with no proof of what they believe because they're in denial of the true facts that crime actually goes down and the revenue it generates to the states are in the millions.. educate yourself before spreading misinformed lies about a subject just because in your opinion you don't like it.. some people like pills, which kills more people than gun violence, and some people don't.  
Posted ON : 01/19/2017
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Ronald Kosanovich: Alan, your a fool. Everyone keeps asking for statistics. Here AAA published stats. Of couse the ones that want drugs ignore these facts. Any impairment is bad and can kill. Remember this when ever you put your own satisfaction over your children's lives while driving. http://newsroom.aaa.com/2016/05/fatal-road-crashes-involving-marijuana-double-state-legalizes-drug/  
Posted ON : 01/19/2017
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Ronald Kosanovich: I could care less what you do with your body. Drink battery acid for all I care. Your problem is the stats above that you refuse to believe. I should be able to kill impaired drivers or ones texting or using cell phones with a gun, just like they're doing.  
Posted ON : 01/19/2017
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RoyandPatricia Hill: Justin Lowe
Posted ON : 01/19/2017
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Ronald Kosanovich: Keep in mind that the illegal drug world has enough power to stop any legislation. Why did it pass so easy, especially when cutting into the huge illegal operations
Posted ON : 01/19/2017
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Ronald Kosanovich: Think about our highways, heavy drug use and your children and grandchildren riding those roads. Check the stats!
Posted ON : 01/19/2017
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Alan Kenyon: You forgot to mention pills which kills more people than gun violence. Pills which has more side effects that can kill you than marijuana. Driving under the influence of pills or alcohol is far more dangerous than marijuana.  
Posted ON : 01/19/2017
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Crystal Anne: Spot on sir. While it can delay actions depending on the potency and strain....driving under pills or alcohol you have far less control. I'm a consumer and I also work in a medical grow facility. Prior to me working there I was just as ignorant as the crap I learned in school about it. All things are bad without moderation. It's called being smart and responsible. I'm more worried about crashing because some jackass is on their phone, than I driving a little lit from cannabis. You can focus when you're high and anyone that says otherwise either has pushed their own limits or never consumed.  
Posted ON : 01/19/2017
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Ronald Kosanovich: Everyone keeps asking for statistics. Here AAA published stats. Of couse the ones that want drugs ignore these facts. Any impairment is bad and can kill. Remember this when ever you put your own satisfaction over your children's lives while driving. http://newsroom.aaa.com/2016/05/fatal-road-crashes-involving-marijuana-double-state-legalizes-drug/  
Posted ON : 01/19/2017
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Jeff Inglese: Ronald if it wasn't for dickheads like you Prohibition never would've happened and our prisons wouldn't be overcrowded. Get over it.  
Posted ON : 01/19/2017
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Annette Baxter: Ronald Kosanovich if you have taken cough syrup and drove, you've been driving under a heavier influence than Marijuana. That AAA report is two years old and bases on older info. Check the current stats. Plus the article is talking about a company making breakthroughs in the industry, it's not talking about driving under the influence. There have been DUI regulations put in place in each state. Why not get on the band wagon to ban alcohol? It's caused more deaths, destroyed more lives than anything on this planet.  
Posted ON : 01/19/2017
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Ronald Kosanovich: Bull, I've done both and you have no idea what you're talking about. Takes awhile for alcohol, but can get high in a few hits. No documentation and total justification is what you want. ANY IMPAIRMENT IS NO GOOD, NO JUSTIFICATIONS.  
Posted ON : 01/19/2017
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Debi Shook-Lloyd: Buzzed, either pot or alcohol, and driving do not mix. The number of drunk drivers far outweigh marijuana users. Alcohol is the most addictive, socially accepted, drug out there!
Posted ON : 01/19/2017
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Mike Kramarenko: I agree with only part of your statement. While drinking and driving is really bad for everyone around them, pot smokers are only out for one thing. Finding the best munchies, and are very cautious drivers.  
Posted ON : 01/19/2017
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Jani Patereau: Recreational marijuana is legal in OR. I see drivers smoking it quite often and the number of accidents where the driver had been smoking pot have gone up significantly. Another side affect is children and pets ending up in the ER because people weren't careful with their "edibles".  
Posted ON : 01/19/2017
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Robert Hoffschneider: Yes
Posted ON : 01/19/2017
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Cindy Daniel: Thank you ♡
Posted ON : 01/19/2017
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George Savvas: Amazing
Posted ON : 01/19/2017
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Ronald Winslow: Cancer cure without negative and life quality side effects.
Posted ON : 01/19/2017
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Tony Giorgeri: I quit 18 years ago, in the end it made me paranoid, antsy, lazy and quiet. Im free.
Posted ON : 01/19/2017
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Anthony Mercado: HAHAHAHAHAHAHAHAHA know how to control yourself 😂😂😂😂😂😂😂😂😂  
Posted ON : 01/19/2017
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Tony Giorgeri: Anthony, when I was very young it was a blast, not so many years later, have fun, stay out of trouble and RESPECT OTHERS  
Posted ON : 01/19/2017
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Teresa Smith: I personally don't use it but I do feel in my heart that it's a cure for cancer and I say if it is let the ones that need it have it in Jesus name amen we all need acure for cancer
Posted ON : 01/19/2017
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Anthony Mercado: That is a cure for cancer  
Posted ON : 01/19/2017
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Walter Dorvin: And making many others stupid!
Posted ON : 01/19/2017
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Golong Kajunki: O yes 420 N.Y.
Posted ON : 01/19/2017
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Marilyn Wade: Total bull
Posted ON : 01/19/2017
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Joshua Walk: Fk ya weed rocks
Posted ON : 01/19/2017
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Van Lamb: I bet you have a great job and can support your habit dumb ass  
Posted ON : 01/19/2017
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Joshua Walk:   
Posted ON : 01/19/2017
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Joshua Walk: Grow it its free dumass  
Posted ON : 01/19/2017
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Rosalynda Longoria: Van, you call Josh a dumbass, but have you ever researched to what is being done with marijuana or taken a look at the testimonies of people who use it? It is in fact you who are the dumbass for following along and being one of the sheeple.  
Posted ON : 01/19/2017
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Candice Hughes: Joshua Walk it's not free dumb ass. Electric,soil , nutrients,water, bug repellent. Fans, grow tent or closet with reflective shit. So much more than just doing it. You don't grow do you?  
Posted ON : 01/19/2017
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Joshua Walk: I'm just talking bout personal use throw a couple if seeds in the ground then smoke pot not that complicated 3r4plants is enough for me seed and dirt and water is all u need and sunlight  
Posted ON : 01/19/2017
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Joshua Walk: Fans and a grow tent lol whoa I'm not running a grow operation lmao  
Posted ON : 01/19/2017
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Alberto Carlo: Its all about money.Once de mafia, sorry the gov have his share in the buss is OK.Just like alcohol buss.The tax it ,now is legal
Posted ON : 01/19/2017
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Scott Hall: Cannabis is great by ITSELF !!! We damn sure don't need labs fucking with it 👎👎
Posted ON : 01/19/2017
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Rosalynda Longoria: Yes, but it would be great if they can figure out how to get it to target areas of disease more effectively.  
Posted ON : 01/19/2017
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Scott Hall: Yes that would be good but they'll only go so far. There is a CURE for the flu & common cold but since otc cold and flu remedies are a 22 BILLION dollar a year industry they'll make it available 👎  
Posted ON : 01/19/2017
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Bill Hern: https://m.facebook.com/photo.php?fbid=868074999915985&id=100001404780023&set=a.672508579472629.1073741827.100001404780023&source=48&ref=m_notif¬if_t=live_video_invite&__tn__=ER&_ft_=
Posted ON : 01/19/2017
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Aaron Cardona: Evil fucks, terrorist your countrymen for weed and then run testing and act like oh wow it really does do good things like you fickij didn't know already, and now your going to allow yourselves and big evil pharma to sell the product and get rich doing so. Shame on you fuck tards
Posted ON : 01/19/2017
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Bonnie Donahue: IT'S BEEN DOING GOOD FOR PEOPLE FOR THOUSANDS OF YEARS! IT NEEDS NO IMPROVEMENT FOR PUBLIC CONSUMPTION! THE ONLY REASON TO "IMPROVE" IT IS SO BIG PHARMA CAN MAKE TONS OF MONEY ON IT AND ATTEMPT TO GET A PATENT! ALL YOU NEED TO DO IS GROW IT YOURSELF!!!! DON'T LET THEM TAKE YOUR POWER!!!!!!
Posted ON : 01/20/2017
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Way V King III: Gloves
Posted ON : 01/20/2017
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Ken Clingman:
Posted ON : 01/20/2017
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Barry Kemple: the US government holds a patent for medical marijuana
Posted ON : 01/20/2017
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Yohon Ham: Nobody can legally have a patent on marijuana because it is a plant just like any other plant that grows on the Earth  
Posted ON : 01/20/2017
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Barry Kemple: you should read the patent Yohon, you should read the patent it's #6630507 and it's a patent for certain medical uses of the extracts of cannabis (marijuana) read it for yourself because you won't believe me if I tell you what those medical uses are.  
Posted ON : 01/20/2017
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Blake Jones: All this patent stuff needs to be destroyed with medical  
Posted ON : 01/20/2017
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Jon Betts: Ronald Kosanovich I don't know were you get your stats from but their inaccurate and probably driven by lobbyist for pharmaceutical's that know legal marijuana would cut into their profits big time. You need to look elsewhere
Posted ON : 01/20/2017
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Timothy Boeset: Medical marijuana is a fallacy. All marijuana is medicine. Adding medical is just a scam to drive more profit.
Posted ON : 01/20/2017
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Nathaniel Anderson: It was already great.
Posted ON : 01/20/2017
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Janet Sipple: aund it has been here all along...should be free to grow..what we do on our property should be our own business, as long as it is not dangerous to others.
Posted ON : 01/20/2017
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Matt Morgan: GMO WEED I WON'T SMOKE OR EAT.
Posted ON : 01/20/2017
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Erin Kulesa: When wasn't it great huh?
Posted ON : 01/20/2017
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Bridget Gossman: Big pharm gets ahold of it and none of us normal people will be able to afford the benefit of it just like with the pills it will b a shame.
Posted ON : 01/20/2017
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Timothy Boeset: They've been trying and failing for 50 yrs. Not likely to happen.  
Posted ON : 01/20/2017
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Yohon Ham: And that is why I grow my own  
Posted ON : 01/20/2017
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Tracy Medsker: Lynn Grider
Posted ON : 01/20/2017
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Mike TheHat: Marijuana was just fine and nothing needed to make it great again. It was never not great. OPP....
Posted ON : 01/20/2017
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Victoria Ward Norman Allen: Sounds like Big Pharma to me!
Posted ON : 01/20/2017
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Shelly Chapa: This needs to go further than just research. ....we need to see the medicinal properties of this herb....it's just STUPID not to recognize it has an tremendous value for PTSD, epilepsy. ...etc.
Posted ON : 01/20/2017
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Rocky Baker: I had surgery ,dr. Gave me pain pills didnt help. Took 2 hits off a joint. Pain was completely gone. Truth. I was ready to go bac to work. After awhile pain came bac. Next day did same thing pain went away. Was ready to go bac to work.  
Posted ON : 01/20/2017
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Debbie Neal: And what is their profit?
Posted ON : 01/20/2017
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Deborah Sue Hicks: Uh, pot has always been great
Posted ON : 01/20/2017
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Mary Chandler: The possibilities are there, explore the uses, we know a lot already, but there are probably many more illnesses it would help!
Posted ON : 01/20/2017
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Liz Thorson: The fuck you mean make it great again? Wasn't it already? Keep your STINKING LAB HANDS OFF MY SHIT!
Posted ON : 01/20/2017
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Dain Oyler: It's called cannabis.. gtfo
Posted ON : 01/20/2017
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Mark Kralicek: Good luck changing people that have called cannabis, Marijuana for 80+ years. No need to rock the boat.  
Posted ON : 01/20/2017
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Mark Kralicek: Companies don't make Marijuana great, organic craft growers make cannabis great.
Posted ON : 01/20/2017
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Angelo Esposito: i'll have some kona bud please !
Posted ON : 01/20/2017
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Judy Rojo: It always was great...
Posted ON : 01/20/2017
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Daniel Ashcraft: Thank god for that company. Nobody else seems to have the knowledge or the balls to get in the weed business.
Posted ON : 01/20/2017
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Bobby Curl: Its perfected in its natural form. Dont need your drugs or permisions
Posted ON : 01/20/2017
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Mike Olah: Making marijuana gay again!
Posted ON : 01/20/2017
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Travis Dolesy: I will avoid this company... I am able to think for myself, I think anyone aligned with dumpster can eat a dick. Make it great fuck that.
Posted ON : 01/20/2017
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Charyl Helton: " components" of cannabis can't work alone.They've been trying this for years. Example: Marinol
All the components are interdependent. Monsanto wants to remove euphoric effect from their GMO cannabis!
Posted ON : 01/20/2017
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Lee Fitzgerald: When big pharmaceutical can make a but load of money, you will still need a scrip for a bullshit drug, trust me
Posted ON : 01/20/2017
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Donald Baird: Remind's me of president chump. Make it great....
Posted ON : 01/20/2017
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Kimberly Carroll: Why do we need THEM??? Marijuana is not truly legal until we can cultivate in all on our own, for our own use
Posted ON : 01/20/2017
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David Arnold: It helps my (TBI) don't care what they say
Posted ON : 01/20/2017
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Quentin McClanahan: I smoked marijuana for close to 25 years... Pretty much every day... Ultimately it made me depressed, anxious, lazy, forgetful, ect., ect., ect....
Posted ON : 01/20/2017
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Mitchell Martin: Well, it had the opposite effect on me after more than 30 years, so, I'm sure it's just you, and not anything to do with cannabis....,  
Posted ON : 01/20/2017
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Quentin McClanahan: It done the same thing to the majority of all my friends who smoked it. Most of them eventually quit once they realized they finally came to terms with how it was actually affecting them... But some people stay so high all the time they are able to notice the negative effects that it's having on them or they just enjoy it to much to care...  
Posted ON : 01/20/2017
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Quentin McClanahan: But I'm glad that it helped you... Different chemicals work differently for everyone because each person has their own unique chemical makeup and response differently to drugs... hopefully you are able to use it in a form that doesn't damage the lungs..  
Posted ON : 01/20/2017
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Quentin McClanahan: I'm not against using drugs of any kind to help with legitimate medical symptoms... However I did not like drugs that bring along a strong intoxication.... a strong intoxication is unwanted by me because of the effect it has on judgement and emotions... I prefer drugs that treat the symptoms without producing a "high"  
Posted ON : 01/20/2017
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Edward Hammond: you were probaly on the edge of being depressed anyway, since it is a downer. i agree on forgetful.  
Posted ON : 01/20/2017
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Gary Criddle: Same shit hear 40+ year's FUCK THE BULLSHIT LEFTUS HYPE
Posted ON : 01/20/2017
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Ruth Sakiestewa: But is that going to be run under BIG PHARMA?*
Posted ON : 01/21/2017
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Ronald Kosanovich: Hope the next doctor that does surgery on your children has a few hits before the operation..
Posted ON : 01/21/2017
user
Ronald Kosanovich: What is that, you're sick justification...
Posted ON : 01/21/2017
user
Ronald Kosanovich: Uses are not going to buy medical crap. All they want is the pass. Illegal drugs are going to sit back and watch their business lose. You people are assholes..
Posted ON : 01/21/2017
user
Ronald Kosanovich: Eventually you're going to hook into that super last high.
Posted ON : 01/21/2017
user
Ronald Kosanovich: I refuse to justify any impairments. That being said, I've had no personal incidents involving drivers under any influence or on a phone. But if my family ever does, then I won't be happy until I have a personal conversation with EVERYONE IN YOUR FAMILY,and it'll take a lot to make me happy. See I believe that every driver should be responsible, and I'll hold them to that.
Posted ON : 01/21/2017
user
Elvia Gomez: yo tuve canser ase 12 años no.nezecite.mariguana.zobre vivi aqui estoy gracias a Dios .
Posted ON : 01/25/2017