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As the 40,000 fans in the crowd began to flee, Yazzi took cover and said he saw flashes of light coming from the Mandalay Bay hotel tower high above.

The area is now on lockdown. All clubs and businesses on the strip are closed.

University Medical Center spokeswoman Danita Cohen said the Las Vegas hospital is taking in people with gunshot wounds. She didn't have any more immediate information.

Zack, who said he was near the stage, told Fox News that his sister witnessed a concertgoer get shot in the head.

Country singer Jake Owen, tweeted, "Gun shots!!! Vegas. Pray to god. Love you guys. Love you Pearl."

The Associated Press contributed to this report

Story Update - 10/2/17 10:46AM via Fox News Partner

The suspect, who died of a self-inflicted gunshot wound, was identified as 64-year-old Stephen Paddock, a resident of Mesquite, Nevada. Police initially sought a womanbelieved to be Paddock's roommate, Marilou Danley, as a "person of interest." Detectives later made contact with her, and "do not believe she is involved with the shooting on The Strip."

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Cellphone video captures moment Vegas shooting started

Clark County Sheriff Joseph Lombardo said an "excess of 10 rifles" were found in the room, but did not immediately reveal a motive. Paddock had been in the hotel room since September 28, according to Lombardo.

Authorities said two on-duty Las Vegas Metropolitan Police Department officers were injured during the shooting. One is in stable condition after surgery, and the other sustained minor injuries. Two off-duty police officers attending the concert were killed.

President Trump tweeted his condolences to the victims of the Las Vegas massacre, saying "My warmest condolences and sympathies to the victims and families of the terrible Las Vegas shooting. God bless you!"

The gunman, who fired down on the Route 91 Harvest Festival from a room on the 32nd floor of the Mandalay Bay Resort and Casino, died from a self-inflicted gunshot wound just as police made entry to the room, according to LVMPD undersheriff Kevin McMahill.

Federal law enforcement sources told Fox News that Paddock "was known to local authorities" in Vegas, and multiple weapons were found in his hotel room.

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President Trump reacts to deadly Las Vegas mass shooting

Blown out windows at the Mandalay Bay Hotel and Casino.  (Fox News)

At this time, federal officials do not see any connection to international terrorism and little is known about Paddock's motivation, sources said. The Islamic State terror group took credit for the Las Vegas shooting, saying the gunman converted to Islam months ago, but provided no evidence back up the claim.